Tyrosol Reduces Amyloid-β Oligomer Neurotoxicity and Alleviates Synaptic, Oxidative, and Cognitive Disturbances in Alzheimer’s Disease Model Mice

【2019】

Kaori Taniguchi (a, Fumiko Yamamoto (a,b, Takuya Arai (b, Jinwei Yang (c, Yusuke Sakai (c,
Masayuki Itoh (d,Naomi Mamada (b, Masayuki Sekiguchi (e, Daisuke Yamada (f, Akiyoshi Saitoh (f,
Fuyuki Kametani (g,Akira Tamaoka (b, Yumiko M. Araki (h, Keiji Wada (e, Hidehiro Mizusawa (i and Wataru Araki (a

a) Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
b) Department of Neurology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
c) Tokiwa Phytochemical Co., Ltd, Sakura, Chiba, Japan
d) Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
e) Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
f) Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan
g) Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan
h) Department of Psychiatry and Behavioral Science, Graduate School of Medicine, Juntendo University, Tokyo, Japan
i) National Center Hospital, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan

DOI 10.3233/JAD-190098