研究報告

2017年度

2017年度における研究発表をご紹介いたします。

Protective effects of Lepidium meyenii (Maca) aqueous extract and lycopene on testosterone propionate-induced prostatic hyperplasia in mice

【2017】

Ying Zou1,2, Waleed Aboshora1,3,4, Jing Li2,3, Tiancun Xiao5 and Lianfu Zhang1,2,3

1 State Key Laboratory of Food Science and Technology, Jiangnan University
2 School of Food Science and Technology, Jiangnan University
3 National Engineering Research Center for Functional Food, Jiangnan University
4 Department of Food Processing Engineering, Faculty of Engineering, University of Al-Imam Almahdi
5 Chemistry Department, Oxford University

PHYTOTHERAPY RESEARCH (2017), DOI: 10.1002/ptr.5838

目の疲れによる症状に対するビルベロン含有食品の改善効果　に関する英語の論文(2017)

【2017】

Effect of a bilberry extract (BILBERON®)-containing diet on the improvement of eye fatigue-related symptoms (II) -A Randomized, Double-blind, Placebo-controlled Parallel-group Comparison Study-
（目の疲れ症状に対するビルベロン含有食品の改善効果）

Tingfu Liang, Shin-ichiro Yamashita, Naoko Suzuki, Asami Nakata, Jinwei Yang, Takahiro Yamada

Jpn Pharmacol Ther　2017　45（9）1523-1534
『薬理と治療』　2017年：45巻9号；1523-1534ページ

【目の疲れの自覚症状があり、日頃から目を酷使する健常な成人男女を対象に、被験者1日当たり160 mgのビルベロンまたはプラセボを6週間摂取する臨床試験を実施しました。（試験食品群 n=10；プラセボ群 n=11）
その結果、ビルベロンを継続摂取することで、ピント調節機能、目の疲れ、肩こりの自覚症状および目の潤いが改善することが確認されました。】

Two flavone C-glycosides as quality control markers for the manufacturing process of ephedrine alkaloids-free Ephedra Herb extract (EFE) as a crude drug preparation(2017)

【2017】

Naohiro Oshima, Takuro Maruyama, Tadatoshi Yamashita, Nahoko Uchiyama, Yoshiaki Amakura, Sumiko Hyuga, Masashi Hyuga, Shunsuke Nakamori, Hiroaki Takemoto, Yoshinori Kobayashi, Takashi Hakamatsuka, Hiroshi Odaguchi, Toshihiko Hanawa, Yukihiro Goda

Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1, Kitakanemaru, Ohtawara city, Tochigi 324-8501, Japan
Division of Drugs, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
TOKIWA Phytochemical Co., Ltd., 158 Kinoko, Sakura-shi, Chiba 285-0801, Japan
Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan
Oriental Medicine Research Center, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
Department of Pharmacognosy, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku,Tokyo 108-8641, Japan
Present Address: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan

Journal of Natural Medicines (2017), DOI 10.1007/s11418-017-1111-8

Effect of an Apocynum venetum leaf extract (VENETRON ®) on sleep quality and psychological stress improvement(2018)

【2018】

Effect of an Apocynum venetum leaf extract (VENETRON®) on sleep quality and psychological stress improvement

（睡眠の質、及びストレスに対するベネトロン®含有食品の改善効果）

Asami Nakata, Shin-ichiro Yamashita, Naoko Suzuki, Tingfu Liang, Tomoko Kuniyoshi, Jinwei Yang, Tsuyoshi Takara

Jpn Pharmacol Ther　2018　46（1）117-125
『薬理と治療』　2018年：46巻1号；117-125ページ

【日頃の睡眠の質に不満を感じている健常な成人男女17名を対象に、被験者1日当たり50 mgのラフマ葉抽出物（ベネトロン®）またはプラセボを8日間摂取する臨床試験を実施しました。
その結果、ベネトロン®を継続摂取することで、睡眠の質（寝つき・熟眠感）の向上、作業に伴うストレス、集中力の維持を改善することが示唆されました。】

Ephedrine Alkaloids-Free Ephedra Herb Extract, EFE, Has No Adverse Effects Such as Excitation, Insomnia, and Arrhythmias


【2018】

Hiroaki Takemoto, Jun Takahashi, Sumiko Hyug,Hiroshi Odaguchi, Nahoko Uchiyama, Takuro Maruyama, Tadatoshi Yamashita, Masashi Hyuga, Naohiro Oshima, Yoshiaki Amakura, Takashi Hakamatsuka, Yukihiro Goda, Toshihiko Hanawa, and Yoshinori Kobayashia

Department of Pharmacognosy, School of Pharmacy, Kitasato University; 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan
Oriental Medicine Research Center of Kitasato University; 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
National Institute of Health Sciences; 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Japan
TOKIWA Phytochemical Co., Ltd., 158 Kinoko, Sakura-shi, Chiba 285-0801, Japan
Faculty of Pharmaceutical Sciences, Tokyo University of Science; 2641 Yamazaki, Noda, Chiba 278-8510, Japan
College of Pharmaceutical Sciences, Matsuyama University; 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan

Biol. Pharm. Bull. 41, 247-253 (2018)

Quantification of terpene trilactones in Ginkgo biloba with a 1H NMR method

【2018】

Tingfu Liang 1, Takuya Miyakawa 2, Jinwei Yang 1, Tsutomu Ishikawa 1, Masaru Tanokura 2

1 Tokiwa Phytochemical Co. Ltd, 158 Kinoko, Sakura, Chiba 285‑0801, Japan
2 Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1‑1‑1 Yayoi, Bunkyo‑ku, Tokyo 113‑8657, Japan

J Nat Med (2018). https://doi.org/10.1007/s11418-018-1203-0

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