研究報告

2018年度

2018年度における研究発表をご紹介いたします。

A Double-Blind, Randomized, Crossover Comparative Study for Evaluating the Clinical Safety of Ephedrine Alkaloids-Free Ephedra Herb Extract (EFE)

【2018】

HiroshiOdaguchi ,1 MarikoSekine ,1 SumikoHyuga ,1 ToshihikoHanawa,1 KeikaHoshi ,2 YoshinobuSasaki,3 MasakoAso,3 JinweiYang,4 MasashiHyuga,5 YoshinoriKobayashi,6 TakashiHakamatsuka,5 YukihiroGoda,5 andYujiKumagai3

1 OrientalMedicineResearchCenter,KitasatoUniversity,5-9-1Shirokane,Minato-ku,Tokyo108-8642,Japan
2 DepartmentofHygiene,KitasatoUniversitySchoolofMedicine,1-15-1Kitasato,Minami-ku,Sagamihara,Kanagawa252-0374,Japan
3 KitasatoUniversityHospitalClinicalTrialCenter,1-51-1Kitasato,Minami-ku,Sagamihara,Kanagawa252-0375,Japan
4 TokiwaPhytochemicalCo.,Ltd.,158Kinoko,Sakura,Chiba285-0801,Japan
5 NationalInstituteofHealthSciences,3-25-26Tonomachi,Kawasaki-ku,Kawasaki,Kanagawa210-9501,Japan
6 DepartmentofPharmacognosy,KitasatoUniversitySchoolofPharmacy,5-9-1Shirokane,Minato-ku,Tokyo108-8641,Japan

Evidence-Based Complementary and Alternative Medicine (2018). https://doi.org/10.1155/2018/4625358

Apocynum venetum Leaf Extract Exerts Antidepressant-Like Effects and Inhibits Hippocampal and Cortical Apoptosis of Rats Exposed to Chronic Unpredictable Mild Stress

【2018】

TingWu,1 XiangtingLi,1 TingtingLi,2 MinCai,1 ZhonghaiYu,1 JingsiZhang,1 ZhennianZhang,1 WenZhang,1 JunXiang,1 andDingfangCai 1

1 DepartmentofIntegrativeMedicine,ZhongshanHospital,FudanUniversity,Shanghai200032,China
2 ShanghaiUniversityofTraditionalChineseMedicine,Shanghai201203,China

Hindawi Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 5916451
https://doi.org/10.1155/2018/5916451

Apocynum venetum leaf extract reverses depressive-like behaviors in chronically stressed rats by inhibiting oxidative stress and apoptosis

【2018】

Xiangting Li a, Ting Wu a, Zhonghai Yu a, Tingting Li b, Jingsi Zhang a, Zhennian Zhang a, Min Cai a, Wen Zhang a, Jun Xiang a, Dingfang Cai a,

a Department of Integrative Medicine, Zhongshan Hospital, Fudan University, China; Institute of Neurology, Academy of Integrative Medicine, Fudan University, Shanghai 200032, China
b Department of Neurology, Shuguang Hospital, Shanghai University Traditional Chinese Medicine, Shanghai 201203, China

https://doi.org/10.1016/j.biopha.2018.01.137

A simple and effective preparation of quercetin pentamethyl ether from quercetin

【2018】

Jin Tatsuzaki1,2, Tomohiko Ohwada2, Yuko Otani2, Reiko Inagi3 and Tsutomu Ishikawa*1

1 Tokiwa Phytochemical Co. Ltd., 158 Kinoko, Sakura, Chiba 285-0801, Japan
2 Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0013, Japan
3 Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0013, Japan

Beilstein J. Org. Chem.
2018, 14, 3112-3121.
doi:10.3762/bjoc.14.291

Endocrine therapy-resistant breast cancer model cells are inhibited by soybean glyceollin I through Eleanor non-coding RNA


【2018】

Tatsuro Yamamoto1,2,6, Chiyomi Sakamoto1, Hiroaki Tachiwana2, Mitsuru Kumabe1, Toshiro Matsui 3, Tadatoshi Yamashita4, Masatoshi Shinagawa5, Koji Ochiai5, Noriko Saitoh1,2 & Mitsuyoshi Nakao1

1 Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan.
2 Division of Cancer Biology, The Cancer Institute of JFCR, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
3 Faculty of Agriculture, Graduate School of Kyushu University, 744 Mototoka, Nishi-ku, Fukuoka, 819-0395, Japan. 4Tokiwa Phytochemical Co. Ltd., 158 Kinoko, Sakura-shi, Chiba, 285-0801, Japan.
5 Kajitsudo Co., Ltd, 1155-5, Tabaru, Mashiki-machi, Kamimashiki-gun, Kumamoto, 861-2202, Japan. 6Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

SCIENTIFIC REPORTS
2018,8:15202. 1-12
DOI:10.1038/s41598-018-33227-y

エフェドリンアルカロイド除去麻黄エキス (EFE)に関する発表

【2019】

エフェドリンアルカロイド除去麻黄エキス (EFE) によるCFA誘発関節炎モデルマウスの機械刺激に対する感受性の低下
○宮嶋 直紀 1,2, 中森 俊輔 1,2, 日向 須美子 2, 南 可惠 1,2, 楊 金緯 3, 内山 奈穂子 4, 日向 昌司 4,大嶋 直浩 5, 天倉 吉章 6, 袴塚 高志 4, 合田 幸広 4, 小田口 浩 2, 花輪 壽彦 2, 小林 義典 1,2
1北里大薬, 2北里大東医研, 3(株)常磐植物化学研究所, 4国立衛研, 5東京理科大薬, 6松山大薬

麻黄に含まれるエフェドリンアルカロイドの自発運動能に対する作用の解析
○黄 雪丹 1,2, 安藤 真紀 1, 尾野 颯哉 1, 張 葉琳 1, 日向 須美子 2, 竹元 裕明 2,3,山下 忠俊 4, 楊 金緯 4, 内山 奈穂子 5, 日向 昌司 5, 大嶋 直浩 6, 天倉 吉章 7,袴塚 高志 5, 合田 幸広 5, 小田口 浩 2, 花輪 壽彦 2, 小林 義典 1,2
1北里大薬 , 2北里大東医研 , 3東邦大薬 , 4（株)常磐植物化学研究所 , 5国立衛研 , 6東理大薬 , 7松山大薬

日本薬学会（第139回、幕張メッセ、2019年）

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