Scientific Papers_2000 ~ 2009

Safety Study of Apocynum venetum L. Extract in Healthy Adults.

【2009】

Jinwei Li-Yang 1, Ippei Tanaka 1, Veronika Butterweck 2, Syujiro Seo 1, Nobuhito Kimura 1, Tomohiko Uchida 3

1 Tokiwa Phytochemical Co., Ltd

2 College of Pharmacy, Department of Pharmaceutics, University of Florida, FL 32610, USA

3 Uchida Medical Clinic

Journal of Nutritional Food, 12(3), 1 -9 (2009)

The Stress Reducing Effect of γ-Aminobutyric Acid and Apocynum venetum Leaf Extract on Changes in Concentration of Salivary Chromogranin A.

【2009】

Ai YOTO 1, Shigemasa ISHIHARA 2, Jinwei LI-YANG 2, Veronica BUTTERWECK 3, Hidehiko YOKOGOSHI 1

1 School of Food and Nutritional Sciences, The University of Shizuoka

2 Tokiwa Phytochemical Co., Ltd

3 College of Pharmacy, Department of Pharmaceutics, University of Florida

Japanese Journal of Physiological Anthropology, 14(3), 55 (2009)

Unique Coordination Mode of Potassium Ions to Glycyrrhizin：X-ray Crystal Structure of Glycyrrhizin Dipotassium Salt (2009)

【2009】

Yasuko In, Masaru Uchida, Masamichi Watanabe, Norio Aimi, and Toshimasa Ishida
Osaka University of Pharmaceutical Sciences, Tokiwa Phytochemical Co., Ltd, Chiba University
Chemistry Letters Vol.38, No.11

Economic importance of licorice (2009)

【2009】

Hiroaki Hayashi, Hiroshi Sudo
Gifu Pharmaceutical University, TOKIWA Phytochemical Co., Ltd.
Plant Biotechnol, 26, 101-104. (2009)

Expressed sequence tags from rhizomes of Glycyrrhiza uralensis (2009)

【2009】

Hiroshi Sudo, Hikaru Sek, Nozomu Sakurai, Hideyuki Suzuki, Daisuke Shibata, Atsushi Toyoda, Yasushi Totoki, Yoshiyuki Sakaki, Osamu Iida, Toshiro Shibata, Mareshige Kojoma, Toshiya Muranaka, Kazuki Saito.
Plant Biotechnol, 26, 105-107. (2009)

Vasorelaxation Mechanisms of Quercetin in Rat Arteries (2009)

【2009】

Seiichiro Nishida, Hiroyasu Satoh
Department of Pharmacology, Division of Traditional Herbal Medicine, Nara Medical University
Journal of US-China Medical Science, 6(10), 54-74, (2009)

Cardiotonic effect of Apocynum venetum L. extracts on isolated guinea pig atrium (2009)

【2009】

Irie K 1, Sato T 2, Tanaka I 3, Nakajima JI 3, Kawaguchi M 1, Himi T 1.

1 Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences, Musashino University

2 Department of Natural Resources and Physiological Chemistry, Graduate School, Tokyo Medical and Dental University

3 Tokiwa Phytochemical Co., Ltd

J Nat Med, 63, 111-116 (2009)

Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice.

【2009】

Grundmann O, Nakajima J, Kamata K, Seo S, Butterweck V.

University of Florida, TOKIWA Phytochemical Co., Ltd.
Phytomedicine, 16, 295-302. (2009)

Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin. (2008)

【2008】

Seki H, Ohyama K, Sawai S, Mizutani M, Ohnishi T, Sudo H, Akashi T, Aoki T, Saito K, Muranaka T.
Proc Natl Acad Sci U S A. , 105(37), 14204-14209. (2008)

Constituents from leaves of Apocynum venetum L. (2008)

【2008】

Kazuaki Kamata, Shujiro Seo, Jun-ichiro Nakajima
TOKIWA Phytochemical Co., Ltd.
J Nat Med, 62, 160-163. (2008)

Suppression of oxidized LDL-induced PDGF receptor beta activation by ginkgo biloba extract reduces MMP-1 production in coronary smooth muscle cells.

【2007】

Akiba S, Yamaguchi H, Kumazawa S, Oka M, Sato T.
Department of Pathological Biochemistry, Kyoto Pharmaceutical University, Kyoto, Japan.
J Atheroscler Thromb., 14(5), 219-225. (2007)

Anti-anxiety Effects of Apocynum venetum L. in the Elevated Plus Maze Test.

【2007】

Oliver Grundmann 1, Jun-Ichiro Nakajima 2, Shujiro Seo 2, Veronika Butterweck 1

1 College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesvilla, FL 32610, USA.

2 Tokiwa Phytochemical Co., Ltd

Journal of Ethnopharmacology, 110(3), 406-411. (2007)

Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral models. (2006)

【2006】

Sakakibara H, Ishida K, Grundmann O, Nakajima J, Seo S, Butterweck V, Minami Y, Saito S, Kawai Y, Nakaya Y, Terao J.
Tokushima University
Biol Pharm Bull., 29(8), 1767-1770. (2006)

Bioavailability and tissue distribution of anthocyanins in bilberry (Vaccinium myrtillus L.) extract in rats. (2006)

【2006】

Ichiyanagi T, Shida Y, Rahman MM, Hatano Y, Konishi T.
Nigata University of Pharmacy and Applied Life Sciences
J Agric Food Chem., 54(18), 6578-6587. (2006)

Superoxide radical- and peroxynitrite-scavenging activity of anthocyanins; structure-activity relationship and their synergism. (2006)

【2006】

Rahman MM, Ichiyanagi T, Komiyama T, Hatano Y, Konishi T.
Nigata University of Pharmacy and Applied Life Sciences
Free Radic Res., 40(9), 993-1002. (2006)

A Novel in vitro Endothelium-dependent Vascular Relaxant Effect of the Apocynum venetum Leaf Extract.

【2005】

Chiu‐Yin Kwan 1, Wen‐Bo Zhang 1, Sansei Nishibe 2, Shujiro Seo 3

1 Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

2 Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

3 Tokiwa Phytochemical Co. Ltd.

Clinical and Experimental Pharmacology and Physiology

Volume 32, Issue 9, 789-95. (2005)

Age-related changes in the vasodilating actions of Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta. (2005)

【2005】

Nishida S, Satoh H.
Department of Pharmacology, Nara Medical University,

Clin Chim Acta. 2005 Apr;354(1-2):141-6. Epub 2005 Jan 19.

Approach to novel functional foods for stress control 5. Antioxidsnt activity profiles of antidepressant herbs and their active components (2005)

【2005】

Mutsuko Shirai, Yoshichika Kawai, Rintaro Yamanishi and Junji Terao
Department of Food Science, Institute of Helth Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

The Journal of Medical Investigation Vol.52 Supplement 2005

Antioxidant activity profiles of antidepressant herbs and their active components (2005)

【2005】

Mutsuko Shirai, Yoshichika Kawai, Rintaro Yamanishi, and Junji Terao
Tokushima University
The Journal of Medical Investigation, vol.52, 2005

Effects of continuous ingestion of green tea or grape seed extracts on the pharmacokinetics of midazolam. (2004)

【2004】

Nishikawa M, Ariyoshi N, Kotani A, Ishii I, Nakamura H, Nakasa H, Ida M, Nakamura H, Kimura N, Kimura M, Hasegawa A, Kusu F, Ohmori S, Nakazawa K, Kitada M.
Chiba University、TOKIWA Phytochemical Co., Ltd.
Drug Metab Pharmacokinet., 19(4), 280-289. (2004)

Comparative Electropharmacological Actions of Some Constituents from Ginkgo biloba Extract in Guinea-pig Ventricular Cardiomyocytes. (2004)

【2004】

Satoh H.
Nara Medical University Pharmacology course
Evid Based Complement Alternat Med., 1(3), 277-284. (2004)

Studies on interactions between functional foods or dietary supplements and medicines. IV. Effects of ginkgo biloba leaf extract on the pharmacokinetics and pharmacodynamics of nifedipine in healthy volunteers. (2004)

【2004】

Yoshioka M, Ohnishi N, Koishi T, Obata Y, Nakagawa M, Matsumoto T, Tagagi K, Takara K, Ohkuni T, Yokoyama T, Kuroda K.
Kyoto Pharmaceutical University
Biol Pharm Bull., 27(12), 2006-2009. (2004)

Studies on interactions between functional foods or dietary supplements and medicines. III. Effects of Ginkgo biloba leaf extract on the pharmacokinetics of nifedipine in rats. (2004)

【2004】

Yoshioka M, Ohnishi N, Sone N, Egami S, Takara K, Yokoyama T, Kuroda K.
Kyoto Pharmaceutical University
Biol Pharm Bull., 27(12), 2042-2045. (2004)

LC/PDA/ESI-MS Profiling and Radical Scavenging Activity of Anthocyanins in Various Berries.　（2004）

【2004】

Nakajima JI, Tanaka I, Seo S, Yamazaki M, Saito K.

J Biomed Biotechnol., 2004(5), 241-247.(2004)

Structural dependence of HPLC separation pattern of anthocyanins from Bilberry (Vaccinium myrtillus L.).　（2004）

【2004】

Ichiyanagi T, Hatano Y, Matsuo S, Konishi T.
Nigata University of Pharmacy and Applied Life Sciences
Chem Pharm Bull (Tokyo)., 52(5), 628-630. (2004)

Simultaneous comparison of relative reactivities of twelve major anthocyanins in bilberry towards reactive nitrogen species.　（2004）

【2004】

Ichiyanagi T, Hatano Y, Matsuo S, Konishi T.
Nigata University of Pharmacy and Applied Life Sciences
Chem Pharm Bull (Tokyo)., 52(11), 1312-1315. (2004)

Kinetic comparisons of anthocyanin reactivities towards 2,2′-azobis(2-amidinopropane) (AAPH) radicals, hydrogen peroxide and tert-buthylhydroperoxide by capillary zone electrophoresis.　（2004）

【2004】

Ichiyanagi T, Hatano Y, Matsugo S, Konishi T.
Nigata University of Pharmacy and Applied Life Sciences
Chem Pharm Bull (Tokyo)., 52(4), 434-438. (2004)

Apocynum venetum extract does not induce CYP3A and P-glycoprotein in rats. (2004)

【2004】

Kobayashi M, Saitoh H, Seo S, Butterweck V, Nishibe S.　

Westfälische Wilhelms-Universität, Health Sciences University of Hokkaido, TOKIWA Phytochemical Co., Ltd., Kyoto Pharmaceutical University
Biol Pharm Bull., 27(10), 1649-1652. (2004)

Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. (2003)

【2003】

Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YM, Passwater R.
J Ethnopharmacol, 87(1), 115-117. (2003)

Mechanisms for the vasodilations induced by Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta. (2003)

【2003】

Nishida S, Satoh H.
Nara Medical University Pharmacology course
Life Sci, 72(23), 2659-2667. (2003)

Effects of ginkgo biloba extract and bilobalide, a main constituent, on the ionic currents in guinea pig ventricular cardiomyocytes. (2003)

【2003】

Satoh H.
Nara Medical University Pharmacology course
Arzneimittelforschung., 53(6), 407-413. (2003)

Studies on interactions between functional foods or dietary supplements and medicines. I. Effects of Ginkgo biloba leaf extract on the pharmacokinetics of diltiazem in rats. (2003)

【2003】

hnishi N, Kusuhara M, Yoshioka M, Kuroda K, Soga A, Nishikawa F, Koishi T, Nakagawa M, Hori S, Matsumoto T, Yamashita M, Ohta S, Takara K, Yokoyama T.
Kyoto Pharmaceutical University
Biol Pharm Bull., 26(9), 1315-1320. (2003)

Comparisons of Anthocyanin Reactivity towards Hydroxyl Radical, Superoxide Anion and Singlet Oxygen.　（2003）

【2003】

Ichiyanagi T, Hatano Y, Matsugo S, Konishi T.
Nigata University of Pharmacy and Applied Life Sciences
New Tech. Med., 4(6), 788-792. (2003)

Long-term effects of an Apocynum venetum extract on brain monoamine levels and β-AR density in rats.

【2003】

Veronika Butterweck 1, Kirsten Simbrey 1, Shujiro Seo 2, Tsutomu Sasaki 2, Sansei Nishibe 3

1 Institute of Pharmacology and Toxicology, Universitätsklinikum Muenster

2 Tokiwa Phytochemical Co. Ltd.

3 Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

Volume 75, Issue 3, 557-564. (2003)
Pharmacology Biochemistry and Behavior, 75, 557-564 (2003)

Scientific Papers

2000 ~ 2009

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