Scientific Papers_Ephedrine Alkaloids-Free Ephedra Herb Extract -EFE-

Effect of Ephedra Herb on Erlotinib Resistance in c-Met-Overexpressing Non-Small-Cell Lung Cancer Cell Line, H1993, through Promotion of Endocytosis and Degradation of c-Met

【2020】

Sumiko Hyuga 1, Masashi Hyuga2, Yoshiaki Amakura3, Jinwei Yang4, Eiko Mori1, Takashi Hakamatsuka2, Yukihiro Goda2, Hiroshi Odaguchi 1, and Toshihiko Hanawa1

1 Oriental Medicine Research Center of Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
2 National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan
3 Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama,Ehime 790-8578, Japan
4 Tokiwa Phytochemical Co., Ltd., 158 Kinoko, Sakura, Chiba 285-0801, Japan

doi.org/10.1155/2020/7184129

Analgesic Effects of Ephedra Herb Extract, Ephedrine Alkaloids-Free Ephedra Herb Extract, Ephedrine, and Pseudoephedrine on Formalin-Induced Pain

【2019】

Shunsuke Nakamori,a,b Jun Takahashi,a,b Sumiko Hyuga,b Jinwei Yang,c Hiroaki Takemoto,a,b
Takuro Maruyama,d Naohiro Oshima,e Nahoko Uchiyama,d Yoshiaki Amakura,f Masashi Hyuga,d
Takashi Hakamatsuka,d Yukihiro Goda,d Hiroshi Odaguchi,b Toshihiko Hanawa,b and Yoshinori Kobayashia,b

a)Department of Pharmacognosy, School of Pharmacy, Kitasato University;
5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan
b)Oriental Medicine Research Center of Kitasato University;
5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
c)Tokiwa Phytochemical Co., Ltd.; 158 Kinoko, Sakura, Chiba 285-0801, Japan
d)National Institute of Health Sciences; 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Japan
e)Faculty of Pharmaceutical Sciences, Tokyo University of Science;
2641 Yamazaki, Noda, Chiba 278-8510, Japan
f)Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University;
4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan

Biol. Pharm. Bull. 42, 1538-1544 (2019)

Quality Evaluation and Characterization of Fractions with Biological Activity from Ephedra Herb Extract and Ephedrine Alkaloids-Free Ephedra Herb Extract

【2019】

Morio Yoshimura,a Yoshiaki Amakura,a Sumiko Hyuga,b Masashi Hyuga,c Shunsuke Nakamori,d Takuro Maruyama,c Naohiro Oshima,e Nahoko Uchiyama,c Jinwei Yang,f Hideki Oka,g Hideyuki Ito,h Yoshinori Kobayashi,d Hiroshi Odaguchi,b Takashi Hakamatsuka,c Toshihiko Hanawa,b and Yukihiro Godac

aCollege of Pharmaceutical Sciences, Matsuyama University
bOriental Medicine Research Center, Kitasato University
cNational Institute of Health Sciences
dDepartment of Pharmacognosy, School of Pharmacy, Kitasato University
eFaculty of Pharmaceutical Sciences, Tokyo University of Science
fTokiwa Phytochemical Co., Ltd.
gZeria Pharmaceutical Co., Ltd., Central Research Laboratories
hDepartment of Nutritional Science, Faculty of Health and Welfare Sciences, Okayama Prefectural University

Chem. Pharm. Bull. 68(2), 140-149 (2020)

A Double-Blind, Randomized, Crossover Comparative Study for Evaluating the Clinical Safety of Ephedrine Alkaloids-Free Ephedra Herb Extract (EFE)

【2018】

HiroshiOdaguchi ,1 MarikoSekine ,1 SumikoHyuga ,1 ToshihikoHanawa,1 KeikaHoshi ,2 YoshinobuSasaki,3 MasakoAso,3 JinweiYang,4 MasashiHyuga,5 YoshinoriKobayashi,6 TakashiHakamatsuka,5 YukihiroGoda,5 andYujiKumagai3

1 OrientalMedicineResearchCenter,KitasatoUniversity,5-9-1Shirokane,Minato-ku,Tokyo108-8642,Japan
2 DepartmentofHygiene,KitasatoUniversitySchoolofMedicine,1-15-1Kitasato,Minami-ku,Sagamihara,Kanagawa252-0374,Japan
3 KitasatoUniversityHospitalClinicalTrialCenter,1-51-1Kitasato,Minami-ku,Sagamihara,Kanagawa252-0375,Japan
4 TokiwaPhytochemicalCo.,Ltd.,158Kinoko,Sakura,Chiba285-0801,Japan
5 NationalInstituteofHealthSciences,3-25-26Tonomachi,Kawasaki-ku,Kawasaki,Kanagawa210-9501,Japan
6 DepartmentofPharmacognosy,KitasatoUniversitySchoolofPharmacy,5-9-1Shirokane,Minato-ku,Tokyo108-8641,Japan

Evidence-Based Complementary and Alternative Medicine (2018). https://doi.org/10.1155/2018/4625358

Two flavone C-glycosides as quality control markers for the manufacturing process of ephedrine alkaloids-free Ephedra Herb extract (EFE) as a crude drug preparation(2017)

【2017】

Naohiro Oshima, Takuro Maruyama, Tadatoshi Yamashita, Nahoko Uchiyama, Yoshiaki Amakura, Sumiko Hyuga, Masashi Hyuga, Shunsuke Nakamori, Hiroaki Takemoto, Yoshinori Kobayashi, Takashi Hakamatsuka, Hiroshi Odaguchi, Toshihiko Hanawa, Yukihiro Goda

Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1, Kitakanemaru, Ohtawara city, Tochigi 324-8501, Japan
Division of Drugs, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
TOKIWA Phytochemical Co., Ltd., 158 Kinoko, Sakura-shi, Chiba 285-0801, Japan
Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan
Oriental Medicine Research Center, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
Department of Pharmacognosy, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku,Tokyo 108-8641, Japan
Present Address: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan

Journal of Natural Medicines (2017), DOI 10.1007/s11418-017-1111-8

Ephedrine alkaloids-free Ephedra Herb extract: a safer alternative to ephedra with comparable analgesic, anticancer, and anti-influenza activities(2016)

【2016】

Sumiko Hyuga, Masashi Hyuga, Naohiro Oshima, Takuro Maruyama, Hiroyuki Kamakura, Tadatoshi Yamashita, Morio Yoshimura, Yoshiaki Amakura, Takashi Hakamatsuka, Hiroshi Odaguchi, Yukihiro Goda, Toshihiko Hanawa

Oriental Medicine Research Center, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1, Kitakanemaru, Ohtawara city, Tochigi 324-8501, Japan
TOKIWA Phytochemical Co., Ltd., 158 Kinoko, Sakura-shi, Chiba 285-0801, Japan
Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan

Journal of Natural Medicines (2016), 70, 571-583

Efficiently prepared ephedrine alkaloids-free Ephedra Herb: a putative marker and antiproliferative effects(2016)

【2016】

Naohiro Oshima, Tadatoshi Yamashita, Sumiko Hyuga, Masashi Hyuga, Hiroyuki Kamakura, Morio Yoshimura, Takuro Maruyama, Takashi Hakamatsuka, Yoshiaki Amakura, Toshihiko Hanawa, Yukihiro Goda

National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1, Kitakanemaru, Ohtawara city, Tochigi 324-8501, Japan
TOKIWA Phytochemical Co., Ltd., 158 Kinoko, Sakura-shi, Chiba 285-0801, Japan
Department of Clinical Research, Oriental Medicine Research Center of Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan

Journal of Natural Medicines (2016), 70, 554-562