Scientific Papers_Black Turmeric

Antiobesity effect of Kaempferia parviflora accompanied by inhibition of lipogenesis and stimulation of lipolysis

【2023】

Seong-Hoo Park¹, Jeongjin Park², Minhee Lee¹, Jinhak Kim³, Sangwon Eun³, Woojin Jun², Ok-Kyung Kim² and Jeongmin Lee¹.

１. Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea

2. Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju, Republic of Korea

3. R&D Division, Daehan Chemtech Co. Ltd. Seoul, Republic of Korea

Food & Nutrition Research

67 (2023)

Anti-Aging Activity of Kaempferia parviflora Extract (SIRTMAX®) and its Standardizing Constituent 3,5,7,3′,4′-pentamethoxyflavone (PURESIRTMAX®)

【2023】

Chin Piow Wong¹, Koji Nagata², Tsutomu Ishikawa¹, Jinwei Yang¹, Jin Tatsuzaki¹

１．Tokiwa Phytochemical Co., Ltd.

２．Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

2023 American Society of Pharmacognosy Annual Meeting (ASP)（USA）

22 July 2023 ～ 26 July 2023
Bethesda North Marriott Hotel & Conference Center

Assessment of in vitro, in vivo, and Clinical Safety of SIRTMAX® a Standardized Kaempferia parviflora Rhizome Extract

【2022】

Chin Piow Wong 1), Yukiko Kobayashi 1), Jinwei Yang 1)

1) Tokiwa Phytochemical Co., Ltd.

Jpn Pharmacol Ther

50 (10) 1889-1899 (2022)

Successful Commercialization of an Anti-Aging Ingredient Based on Advanced Research: Latest Advancement of SIRTMAX®( Kaempferia parviflora extract) in SIRT1 Activation and Clinical Study

【2022】

Jin Tatsuzaki

Tokiwa Phytochemical Co., Ltd.

International Conference of the Modernization of Chinese Medicine & Health Products (ICMCM) 2022（HongKong）

11 August 2022 ～ 12 August 2022
※Onsite & Online Hybrid

The functions of Kaempferia parciflora extract SIRTMAX^® and Kaempferia parciflora-derived polymethoxyflavonoid PURESIRTMAX^® through SIRT1 activation

【2021】

Haruno HONDA, Jinwei YANG

Tokiwa Phytochemical Co. Ltd.

Journal of Japanese Society for Medical Use of Functional Foods
Vol.15 No.2 (2021)

The activation mechanism of longevity gene product SIRT1 by black turmeric polyphenol

【2021】

Mimin Zhang¹ , Jin Tatsuzaki² , Koji Nagata¹

1 Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
2 Tokiwa Phytochemical Co. Ltd.

BIOSCIENCE & INDUSTRY
Vol.79 No.5 (2021)

Quercetin 3,5,7,3’,4’-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1

【2021】

Mimin Zhang¹ , Peng Lu¹ , Tohru Terada^2,3, Miaomiao Sui¹ , Haruka Furuta^1,4, Kilico Iida^1,5, Yukie Katayama¹ , Yi Lu¹ , Ken Okamoto¹ , Michio Suzuki¹ , Tomiko Asakura¹, Kentaro Shimizu^2,3, Fumihiko Hakuno^1,4, Shin-Ichiro Takahashi^1,4, Norimoto Shimada⁶, Jinwei Yang⁶ , Tsutomu Ishikawa⁶ , Jin Tatsuzaki⁶ , Koji Nagata^1,3

1 Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
2 Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
3 Agricultural Bioinformatics Research Unit, Graduate School of Agricultural and Life Sciences, The University of Tokyo
4 Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo
5 Division of Food and Nutrition, Graduate School of Human Sciences, Kyoritsu Women’s University
6 Tokiwa Phytochemical Co. Ltd.

Communications Biology (2021)

URL : https://www.nature.com/articles/s42003-021-01705-1

Potential Therapeutic Agents, Polymethoxylated Flavones Isolated from Kaempferia parviflora for Cataract Prevention through Inhibition of Matrix Metalloproteinase-9 in Lens Epithelial Cells

【2019】

Yoshiki Miyata,a Jin Tatsuzaki,b Jinwei Yang,b and Hiroshi Kosano,a

a)Faculty of Pharma-Sciences, Teikyo University; 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan
b)Tokiwa Phytochemical Co., Ltd.; 158 Kinoko, Sakura, Chiba 285-0801, Japan.

Biol. Pharm. Bull. 42, 1658-1664 (2019)

Effect of Continuous Ingestion of Kaempferia parviflora Extract (SIRTMAX®)-containing Diet on Glycemic Control and Safety Evaluation of Excessive Intake

【2019】

Tomoko Kuniyoshi,1 Yukiko Kobayashi,1 Norimoto Shimada,1 Jinwei Yang,1
Shin-ichiro Yamashita,2 Naoko Suzuki,2 and Tsuyoshi Takara3

1)Tokiwa Phytochemical Co., Ltd.
2)ORTHOMEDICO Inc.
3)Medical Corporation Seishinkai, Takara Clinic

Jpn Pharmacol Ther 2019; 47(11): 1841-50

A simple and effective preparation of quercetin pentamethyl ether from quercetin

【2018】

Jin Tatsuzaki1,2, Tomohiko Ohwada2, Yuko Otani2, Reiko Inagi3 and Tsutomu Ishikawa*1

1 Tokiwa Phytochemical Co. Ltd., 158 Kinoko, Sakura, Chiba 285-0801, Japan
2 Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0013, Japan
3 Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0013, Japan

Beilstein J. Org. Chem.
2018, 14, 3112-3121.
doi:10.3762/bjoc.14.291

ANTI-GLYCATION ACTIVITY OF KAEMPFERIA PARVIFLORA EXTRACT (SIRTMAX®) AND ITS EFFICACY ON METABOLIC SYNDROME(2016)

【2016】

Tingfu Liang and Jin Tatsuzaki
Tokiwa Phytochemical Co. Ltd.

IMARS HIGHLIGHTS Volume 11, Number 2, Mar. 17, 2016

Evaluation of the Safety and Efficacy of Kaempferia parviflora Extract（SIRTMAX®）in Human (2015)

【2015】

―A Randomized Double‒blind, Placebo‒controlled Crossover Clinical Study―

Norimoto Shimada, Asami Nakata, Jinwei Yang, Jin Tatsuzaki, Tomohiko Uchida, Kohji Shirai

Tokiwa Phytochemical Co., Ltd., Uchida Medical Clinic,
Department of Vascular Function, Sakura Hospital, Toho University

Jpn Pharmacol Ther（薬理と治療）Vol.43, No.7 (2015) 997-1005.

Potent SIRT1 Enzyme-stimulating and Anti-glycation Activities of Polymethoxyflavonoids from Kaempferia parviflora (2014)

【2014】

Asami Nakata, Yuka Koike, Hirofumi Matsui, Tsutomu Shimada, Masaki Aburada, Jinwei Yang
TOKIWA Phytochemical Co., Ltd.、Showa University、University of Tsukuba、Musashino University

Natural Product Communications Vol. 9 (9) 2014 p. 1291-1294

Research and Development of Kaempferia Parviflora Extract, SIRTMAX, for Endocrine-metabolic Diseases as a Functional Food (2014)

【2014】

Jin Tatsuzaki
TOKIWA Phytochemical Co., Ltd.
The 13th International Conference & Exhibition of the Modernization of Chinese Medicine & Health Products (ICMCM)